The effect of drug Ezetimibe in the treatment of Ebola

The effect of drug Ezetimibe in the treatment of Ebola
Ali Khanifar,^1,* Rezvan Cheraghale,²
1. Kurdistan university of medical sciences
2. Islamic azad university Dezful
Introduction: In this article are paid to effect of drug Ezetimibe in the treatment of disease Ebola. As in article is called this drug disable this protein in the body is prevent treat disease. in fact this protein carry Ebola virus that by drug this protein disabled and can not carry the virus with your. In fact, this drug is a supplier of antigen to antibodies.
Methods: • As you know, the Ebola virus RNA virus in the family is Filoviridae. The virus then enters the body, and hemorrhagic fever is a disease that is fatal in 50 to 90 percent of patients will be symptomatic. Of course, from 4 species only leads to an asymptomatic infection and will not lead to death. Niemann-pick c1 receiver in research is absolutely essential for virus replication and traumatic. This receptor on hepatocytes and macrophages are actually located. This receptor as well entry cholesterol in these cells. In an article published so far, I found that only 10 percent survive of people patients with Ebola virus .I arrived at the conclusion that people rescued from the Ebola with hypercholesteromia protein that carries cholesterol in the name. I read many articles about the of Niemann pick c1 like 1. As well as the effect of Ezetimibe on the protein Niemann pick c1 like 1. In fact, according to this theory Ebola virus through the proteins Niemann pick c1 like 1 to the cells goal is transmitted through the receiver Niemann pick c1 enter cell and replication starts ,however, it should be noted that the protein Niemann pick c1 like 1 responsible for carrying cholesterol in the hepatitis and macrophages . In research on Niemann pick c1 like 1 protein was concluded that the protein is a protein in enterocytes of jejunum for absorption of cholesterol in the intestine is very important. In this theory people have hypercholesteromia of saved to be Ebola disease. because cholesterol with protein Niemann pick c1 like 1 connected and virus can not binding to protein Niemann pick c1 like1 and will be exposed to the antibodies.as mentioned protein Niemann pick c1 like1 carries cholesterol to hepatitis and macrophages. It should be noted that macrophages play a role in reverse cholesterol transport.
Results: if patients with Ebola be drug Ezetimibe due to disable the protein Niemann pick c1 like1, Ebola virus is exposed to antibodies .of course antibodies is most effective defense against Ebola virus.in fact ,Ezetimbe is a supplier of antigen in the body .Of course, in the last one research on the Ebola virus, Professor Pardis sabeti the Professor at Harvard university is acknowledged that study on the genes people rescued from the disease Ebola concluded these are people with Hypercholesteromia.
Conclusion: As explained in the article, it can be concluded that in patients with Ebola after receiving Ezetimibe drug due to the high affinity of this drug to the receptor Neiman pick c1 like 1 prevent the virus from entering the cell and thus cause visibility The virus will enter the immune system.
Keywords: : Ebola-NPC1L1-NPC1-Ezetimibe