• The effect of the hematopoietic stem cells (HSCs) aging in human life span
  • Pooneh Yasamineh,1 Saman Yasamineh,2,* Mahdi Norouzi,3
    1. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
    2. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
    3. Istanbul University, Department of Molecular Biology and Genetics, Istanbul, Turkey


  • Introduction: Novel blood cells are constantly generated from the hematopoietic stem cells (HSCs), which inhabit in the bone marrow (BM). During the life-span of the organism, this stem cell storage protects life. However, HSCs can persevere in vivo prolonged than one longevity, with senescent, HSC regenerative capability reduces and skewing from lymphopoiesis toward myelopoiesis happens. In addition, the increase in the senescent HSC pool prepares adequate, yet unusual, blood generation. Here we review our current understanding of the molecular mechanisms that contribute to HSC aging. Age-dependent alterations in HSC are included to DNA damaged, the epigenetic landscape, and metabolic stress. As many hematological pathologies are powerfully age-related, strategies to intervene in aspects of the stem cell aging process may have significant clinical relevance.
  • Methods: In this review we used online database such as NCBI (PubMed), and Google scholar. This Research is the result of a survey of more than 175 articles of which 113 articles are directly used in this study.
  • Results: As discussed in this review, studies have pointed toward intrinsic deficiency in HSC function, and epigenetic dysregulation as main contributing factors behind HSC reduction and malignancy during senescent. Gene expression investigations and as well as mouse models demonstrate that DNA modification pathways and preservation of genomic resistance could be one of the cause arose for aging in HSCs. Damage of epigenetic regulation possible account for those aberrant gene expression seen throughout senescent.
  • Conclusion: Many important pathway and molecular function in young and aging HSCs are unknown. Thus, further studies are necessary to pinpoint this relationship and how it changes during aging. However, recently study of the molecular regulation of stem cell function and the mechanisms that go awry during aging is rapidly expanding due to technological advances such as identification of aging markers. Accordingly, future studies will elucidate the inter-play among these possible mechanisms. Via excellent comprehension HSC senescent we can be able to improve the damage of regenerative capability of elderly HSCs.
  • Keywords: HSCs, Aging, DNA damage, Epigenetic, Metabolism