• The major role of Interleukin-6-174G>C gene polymorphism in prognosis of different cancer types
  • zakieh rostamzadeh khameneh,1,*
    1. Department of medical laboratory sciences, Urmia university of medical sciences,urmia,iran


  • Introduction: introduction: The cancer prognosis influenced by the cancer type, stage of tumor and nominated treatment choices. Primary identification and precise prognosis prediction is foremost issue in cancer managements. In this regards, Inflammation has a very vital contribution to cancer progression since malignant cells are certified by the inflammatory cytokines in a microenvironment are to be extremely proliferative. Interleukin-6 (IL-6) has a key factor in inflammation which is engaged in the cancer development pathogenesis. IL-6-174G>C polymorphism and its impacts on protein and gene expression of IL-6 has been revealed in abundant surveys.in this study we focused on the main role of interleukin -6-174G>C gene polymorphism in cancerous affected subjects.
  • Methods: Methods; : As a theoretical study, our extracted date were obtained by searching cancer , inflammation , and 174G>C gene polymorphis keywords in Science direct, Pubmed and Scopus websites in relations of content .This items was written according to preferred articles.
  • Results: Results ; In this regards association between IL-6-174G>C polymorphism and overall survival (OS) of cancer by qualified surveys with various patients involved. Studying different Meta-analysis exhibited that IL-6-174G>C polymorphism is and not related to OS but evaluated by innumerable genotype comparison for instance; GG/(GC+CC), CC/(GC+GG) and CC/GG. Former studies display that, individuals with IL-6-174GC genotype had decreased hazard of poor OS versus GG. Nonetheless, for GG/(GC+CC) genotype assessment, this SNP is affect subjects’ OS apparently in some neoplasms, nonetheless pooled outcomes presenting negative relationships since contrary and protective impact on innumerable type of cancer balance each other.
  • Conclusion: Conclusion : Overall it could be concluded that IL-6-174G>C polymorphism might has imperative role in controlling OS in several cancer types comprising CLL and might associated with patients treatment in the future.
  • Keywords: polymorphism , interleukin 6, genotype