The effect of terhalose on the removal of beta-amyloids

The effect of terhalose on the removal of beta-amyloids
Fahiemeh Bahramnejad,^1,* mojtba mortazavi,²
1. Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
2. Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
Introduction: Trehalose is a nonreducing disaccharide that naturally available (found in diverse organisms such as plants, bacteria, yeast, fungi, mushrooms and insects). In many neurodegenerative disorders like Alzheimer’s, Parkinson’s, or Huntington’s disease, it was found that abnormal aggregation and deposition of specific proteins occurs
Methods: From the studies and articles we have examined, we have concluded that Terhalose also has a chaperon- like activity and the ability to modulate inflammatory responses has also been reported.
Results: Numerous studies have proven that Trehalose limits these processes and the inhibits formation of neurotoxic amyloids. Trehalose may be used in drug design procedures. it may be used in drug encapsulation because it is non-toxic and effective in formation of neurotoxic in certain disorders. It has a chaperone‐like activity, prevents protein misfolding or aggregation, and by promoting autophagy, contributes to the removal of accumulated proteins (B amyloid).
Conclusion: trehalose can activate autophagy via PI3K/Akt/mTOR, AMPK/ULK1/ mTOR, Bcl‐2/Beclin‐1, and TFEB pathways.These pathways regulate authophagy eukaryotic cells.
Keywords: Trehalose,B-amyloid,Autophagy