The role of hotair lncrna as a marker for the prevention and diagnosis of lung cancer

Marjan Zarif yeganeh,1,* Hanieh pourkalhor,2



Background: since lung cancer is one of the most common cancer cases in iran and the world, a large proportion of patients with this cancer are diagnosed at a stage of the disease that conventional therapies do not have an effect on prolonged lifetime of patients and invasion and metastasis it ultimately leads to the death of patients.the necessity of recognizing molecular mechanisms at the beginning, progression and especially invasion and metastasis of the lung tumors to introduce molecular markers for early diagnosis, prognosis and, ultimately, treatment of this cancer is very much needed.


Research method: a review article is a collection of information from up-to-date articles in the pubmed, google scholar databases, ncbi.


Results: hotair has been cooled down and rna has been supplemented with 2185 nucleotides and six exons. this rna is an oncogenic agent that can be used as a diagnostic biomarker for various cancers, and plays a key role in the onset and progression of cancers. in addition, it has been shown there is a significant relationship between hotair relative expression in tumor and metastasis of lung cancer, so that the mean of this gene expression in metastatic patients is higher than non-metastatic.


Conclusion: the results of the studies of this gene may be effective in the future diagnostic management of patients with lung cancer. the measurement of the level of the expression of the hotair gene can help us to find out the progression of cancer levels and make it possible to survive individually predict.


Lung cancer, hotair gene, metastasis