Evaluation of biosensors classification for detection of osteoporosis

Mohammad Hadian jazi,1 Elham sheikhi,2,*

1. Student Research Committee, Islamic Azad University Tehran Medical Branch
2. Department of Clinical Biomedical Engineering, Tehran Medical Sciences Branch, Islamic Azad University



Bone is an active organ with the capacity of continuous remodeling throughout adult life. bone health depends on how the cellular mechanisms in the body create balance in the remodeling process. osteoporosis is the foremost common metabolic bone disorder characterized by a basic disintegration of bone tissue driving to an expanded chance of break. it is a silent disease in numerous circumstances may causes a feared complication such as hip and break with is related expanded morbidity and four times higher mortality within the elderly population so being a critical public health issue of the elderly, it is predictable and by early detection the heavy burden cost that imposes on the society and the one of devices that help to early detection of osteoporosis is biosensor. in fact biosensors are devices during which there’s a coupling of biological detector whit a detector system employing a transducer. biosensors discuss with ‘easy to use’ devices that are developed to assist in the early diagnosing and treatment of malady.


Given the fact that osteoporosis is a disease of the disease, and there are currently no proper methods available, we have looked into this disease and solutions. it should be noted that by first examining existing methods and studying several articles on osteoporosis, and the current methods of diagnosis, we conclude that these methods are not suitable for diagnosis, and the patient becomes aware of his illness when one of his members is seriously injured. in the sequel, we examined the diagnostic biosensors and their structure, and finally, bone biosensors were expressed. biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics and biomedical research. a wide range of techniques can be used for the development of biosensors. their coupling with high-affinity biomolecules allows the sensitive and selective detection of a range of analytes.


Current advancements in bone biosensors recently, technological advancements in biosensors have per-mitted assessment of the biomechanical quality moreover as the metabolic standing of bone. these investigations and improvements have been increased the operation of obtainable biosensors and developed inexpensive, fast, reliable and sensitive point-of-care devices. in spite of the great sensitivity and selectivity, the use of such techniques has huge limitations because of the high equipment cost and the labor involved. prevention of bone deterioration in early stages highly depends on the sensitivity of the bone to mechanical signals, which is crucial in defining, maintaining, and recovering bone mass. measuring bone surface strain in-vivo would be invaluable for studying the structural effects of osteoporosis. for this purpose, in this section a number of biosensors have been proposed.


Osteoporosis, named as a “silent killer” is turning into a lot of prevailing bone degeneration illness in society. besides the present clinical treatment of pathology, it might be a lot of useful to develop associate degree in place sensing element to notice the strain of living bones or notice specific proteins (biomarkers or signal molecules within or outside of the bone cells) for the first designation of pathology. this review seeks to produce associate degree insight into the present progressive materials and technologies within the bone biosensing element field for osteoporosis diagnosis. as biomedical engineering science becomes a bigger part of multiple sectors, together with physics magnets, optics, information technology, martial development, and drugs, medical analysis goes to maneuver quickly into a future wherever scientists, engineers, and clinicians may work along to develop smart biosensors to observe various conditions inside the body. biosensors will have nano-technological elements or will be engineered at the nano-scale themselves. due to their little size, nano-scale devices will pronto move with biomolecules on the surface of or within the cells. the engineers can work on the event and fabrication of the biosensor devices with the assistance of medical researchers to trot out vital biological questions and also the clinicians to deal with sensible problems.


Bone health, metabolic disease, osteoporosis detection, osteoporosis biosensors advancements