Anti-inflammatory activity of rubiadin in carrageenan induced paw edema method in rat

Atefeh Zarezadeh,1,* Zahra mousavi,2 Jinous asgarpanah,3 Parvaneh najafizadeh,4

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran (IAUPS).
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran (IAUPS).
3. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran (IAUPS).
4. Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran.

Abstract

Introduction

Rubiadin is a bioactive anthraquinone with reported antioxidant and antifungal features from the rubiaceae family. we were promoted assess the anti-inflammatory activity of rubiadin using carrageenan induced paw edema method in rats.

Methods

: the acute anti-inflammatory effects of rubiadin (0.3 and 0.5 mg/kg ip) were studied by carrageenan induced paw edema method in 30min,1,2,3 and 4 hr after carrageenan injection. control and standard groups received vehicle and mefenamic acid (30 mg/kg ip), respectively. statistical significance was determined by one-way analyses of variance, followed by the tukey test using graphpad prism 6.

Results

In carrageenan test, all studied doses of rubiadin significantly reduced the paw edema in comparison to the control animals (p<0.05). the anti-inflammatory activities of rubiadin (0.5 mg/kg) was the same as mefenamic acid (30 mg/kg).

Conclusion

The results suggest that rubiadin has significant anti-inflammatory effects.

Keywords

: rubiadin, anthraquinone, anti-inflammatory activity, carrageenan induced paw edema method, rat.