Diabetic nephropathy (dn) is one of the most common causes of end stage renal disease (esrd).: myosin heavy chain 9 (myh9) gene polymorphisms have been implicated in a different type of renal disease as well as nephropathy attributed to type 2 diabetes mellitus.this study aimed to examine the effect of rs4821480 of myh9 gene polymorphism on urinary albumin excretion and glomerular filtration rate (gfr) among iranian diabetic patients and also analyze the association of myh9 gene polymorphism (rs4821480) with dn in the participants.
Methods
In this case-control study, 201 diabetic patients with and without dn (who referred to diabetes and metabolic center, tehran, iran) in two groups were studied. allele and genotype frequencies of rs4821480 were determined using arms-polymerase chain reaction (arms-pcr). in both groups, the blood level of fasting glucose, hba1c, urea, creatinine, uric acid, lipid profile and also urine albumin and creatinine were measured and gfr was calculated.
Results
Patients who carried the rs4821480 polymorphism had significantly higher urinary excretion of albumin (p<0.05) and insignificant lower gfr values (p: 0.08). frequency of rs4821480 snp was 22.8% in patients without dn versus 28% in dn group which was not statistically significant. only 2% and 3% of patients without dn and dn group had two copies of the c allele, respectively. no significant association was found between the rs4821480 polymorphism and dn [or (95% ci): 1.56 (0.79-3.08), p: 0.19].
Conclusion
Although we found the association between myh9 gene polymorphism and urinary albumin excretion, this study didn’t show significant association of myh9 polymorphism (rs4821480) and risk of dn in the iranian diabetic patients.
