1. university of tehran 2. university of tehran 3. university of tehran
Abstract
Introduction
Lung cancer is one of the most common and malignant cancer in both sexes. the prevalence and spread of cancer in iran and the world has been resulted in the producing and using of the drugs with less side effect and less drug interaction and better therapeutic effects. curcumin, active ingredient of turmeric, has anti-cancerous and anti-oxidant properties, but it is unstable and has a slightly solubility in water. therefore, stability and solubility of the curcumin can be enhanced by encapsulating it in drug carriers such as liposomes. liposomal vesicles contain two layers of the phospholipids produce in the aqueous envirnoment. using liposome as a carrier results less polyphenol but with more anti-cancer effects and less toxicity. the obtaining an optimal formulation of curcumin containing liposomes and its affect lung cancer cells is the purpose of this study.
Methods
Liposomes containing curcumin were prepared by thin-film hydration which used lipid, cholesterol and curcumin to produce it. after synthesizing liposome size, zeta potential and encapsulation were investigated.
Results
The testing results showed that curcumin containing liposomes which used a thin-film hydration method were successfully prepared. the results indicated the size of nano-particles and zeta potential were 158.6 nm and -33.14, respectively, and the value of the encapsulation in the optimal form was 73.28±3.16.%.
Conclusion
Our studies demonstrated curcumin is a potent anti-cancer drug that binds to liposomes effectively. in order to increase antitumor efficacy curcumin for lung cells.
Keywords
Liposome, curcumin, anti-cancer, encapsulation, lung cancer
