Effect of hemodialysis on antioxidant enzyme levels in non- diabetic dialysis patients

Maryam Rigi,1,*



Dialysis patients are at a high risk for oxidative stress, resulting in an imbalance between the formation of free radicals and their antioxidant defense mechanisms. this imbalance is the result of the presence of uremic toxins with pro-oxidant properties, increased free radical production due to activation of leukocytes and defective antioxidant defense system. the aim of this study was to evaluate the effect of blood dialysis on the level of antioxidant enzymes in dialysis patients by measuring the level of antioxidant glutathione peroxidase, superoxide dismutase and catalase.


The statistical data in this study included thirty-one dialysis patients from two males and females aged 25-50 years old who were similar in terms of underlying illness these patients were on dialysis 3 times a week . blood samples were taken before and after dialysis and the enzyme levels in the blood were determined.


The results showed mean changes in antioxidants before dialysis in compared with after dialysis.the results showed that after dialysis, superoxide dismutase level decreased by 11/36%, which was statistically significant (p <0.05) and glutathione peroxidase level decreased by 2/01%, which was statistically significant (p <0.05) and catalase levels decreased by 3.26%, which was statistically significant (p <0.05).


Results showed that hemodialysis reduces the level of antioxidant enzymes in patients with dialysis. reducing the level of antioxidant enzymes in hemodialysis patients plays an important role in exacerbating oxidative stress and progressing cardiovascular diseases. therefore, the necessary efforts to reduce these changes have a significant effect on improving the antioxidant status and improving the quality of life of these patients


Oxidative stress , renal failure , dialysis , lipid peroxidation, antioxidant enzymes