Tumor markers are substances produced by the tumors or by other cells of the body in response to cancer. they are produced at much higher levels in cancerous conditions. breast cancer, testicular cancer and lung cancer is one of the most common malignancies in worldwide. the ca 27-29, ca 15-3, ca27.29, p53, cathepsin d, cyclin e, nestin and her-2 are tumor markers that are often expressed in people with breast cancer. afp and hcg are tumor markers in testicular cancer. the most clinically relevant dna biomarkers are egfr, alk, met, ros-1, and kras and currently known protein biomarkers include a2/b1, and cea (carcinoembryonic antigen) are tumor markers that are often expressed in lung cancer. identification of certain potential tumor marker in cancer new approach to modern management diagnostic and treatment.
The articles found were divided into groups according to whether they focused on all tumor marker in this study. studies were also grouped according to whether they analyzed the diagnostic, prognostic or predictive value. also the potential role of the kind of biological material used as sample for cea and other tumor markers measurement was reviewed. statistical significance defined as a p-value < 0.05. a study was classified as “positive” if the results showed a statistic significant difference in prognosis between groups of patients with different levels of tumor marker
They play a crucial role in diagnosis, monitoring response to therapy, early detection of metastasis and determination of recurrence in patients with several cancer. among a total of 217 articles initially discovered, 80 articles fulfilled inclusion criteria.
Finally, thus identifying new biomarkers can be helpful in planning for prevention, diagnostic programs and even predictions for supply necessary health care in the future, especially in our country