Inflammatory markers, vitamin d status and foki polymorphism of the vdr gene in overweight women

Samira Ebrahimof,1,* Seyedeh vahideh pishvae,2 Somayeh abedini,3 Sakineh shab-bidar,4 Mehdi hedayati,5

1. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medica
2. Islamic Azad University, Tehran Medical Branch, Tehran, Iran
3. National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti Uni
4. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences
5. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University

Abstract

Introduction

The present study aimed to evaluate the relationship between inflammatory markers, vitamin d status and foki polymorphism of the vdr gene in overweight young women.

Methods

A sample of overweight (25<bmi<30 kg/m2) women with hypovitaminosis d (25(oh)d<75nmol/l) was studied. inflammatory markers including hs-crp, tnf-a and il-6 were evaluated in serum and peripheral blood cells. foki polymorphism (rs2228570) was detected using pcr-sequencing. serum 25(oh)d was measured using elisa kit. participants were divided into three groups including severe deficient, deficient and insufficient according to their serum vitamin d levels.

Results

Participants had mean age of 36.9±6.9 years and bmi of 28.2±1.8 kg/m2. the mean 25(oh)d was 11.5±6.8 nmol/l. the foki polymorphism showed allelic frequencies of f 74% and f 26%, in the general studied population. in the vitamin d deficient group, tnf-a level was significantly higher in women with the ff genotype compared to women with ff/ff genotype (45.3±5.5 vs. 37.3±6.5 pg/mgpro). in the vitamin d insufficient group, il-6 level was significantly lower in women with ff genotype compared to women with the ff/ff genotype (3.9±0.4 vs. 5.2±1.0 pg/mgpro).

Conclusion

In conclusion, foki genotypes modulate the association of vitamin d and inflammatory markers in iranian overweight women.

Keywords

Inflammatory markers, vitamin d, foki polymorphism, overweight