Molecular markers in the diagnosis of lung cancer
Hamed Heidary,
1,* Tavallaie mahmood,
2
1. Hamed Heidary, Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Scien
2. System Biology Institute, Chemical injuries Research Center, Baqiyatallah Medical Sciences University, Tehran, Iran
Abstract
Introduction
Lung cancer is the leading cause of cancer-related mortality, one of the main causes of mortality by 2010. there are several prognostic factors for the diagnosis of lung cancer including mir, free dna in the blood, methylation, serum and gene biomarkers. in this study, we have a comprehensive overview of these factors, to better understand the biomarkers as well as some diagnostic kits involved in early detection of lung cancer
Methods
Key words including biomarker in lung cancer, lung cancer, was investigated in validated medical databases, especially pubmed until 2017. articles with the most complete description of biomarkers were collected and further studied.
Results
Mir-15a / mir-16 are probably involved in nsclc tumors. mir-146a is a prognostic marker in nsclc that prevents invasion and may be a therapeutic strategy for nsclc. also, providing of tumor genomic profiles by ngs technology for free dna in the bloodstream, improves treatment management. the epi prolung bl reflex assay kit, can be used to test the genes that have been methylated in lung cancer. four serum proteins including carcinoembryonic antigens, retinol binding proteins, anti-trypsin 1α and squamous cell carcinoma antigen, effectively recognizes patients with lung cancer.
Conclusion
The ngs multi-gene panel is currently available to patients with pulmonary adenocarcinoma and several biomarkers have emerged as predictive and diagnostic markers for nsclcs. early diagnosis is necessary to reduce mortality from lung cancer, and proprietary treatments improve response to treatment based on functional or genetic markers.
Keywords
Lung cancer- methylation- mirna in lung casncer
