Frequent use of highly concentrated solutions may induce toxic side effects and cellular damage at the ocular surface. to enhance the amount of active substance reaching the target tissue or exerting a local effect in the cul-de-sac, the residence time of the drug in the tear film should be lengthened. in this paper, eudragit nanoparticles were prepared and incorporated in hydroxy ethyl cellulose films to investigate the effect of nanoparticles on the ocular drug delivery.
A novel quasi-emulsion solvent diffusion method to prepare the controlled-release nanoparticles of drug model with eudragit polymers has been developed. ft-ir and scanning electron microscopy (sem), loading analyses of the nanoparticles, mechanical properties, water vapor permeability, thermal stability of the films were analyzed.
Technique was conveniently modified in order to produce nps-loaded film. in vitro release studies, performed under sink conditions, revealed a fast release during the first hour followed by a more gradual drug release during a 50-h period. the drug release rate from the nps could be controlled by the type and the concentration of polymer formulated.
Azithromycin loaded eudragit were successfully prepared by spontaneous emulsiﬁcation technique. the obtained results showed that eudragit could be a useful nanocarrier for antibiotical drugs. the use of a water-soluble polymer enhanced the contact time and possibly also the penetration of the drug in nanoparticles.
Nanoparticles, film, ophthalmic drug delivery, ocular insert, azithromycin