A review of the fungi generating the cellobiose dehydrogenase enzyme to remove bacterial biofilms

Ramin Rasouli,1 Masoumeh navidinia,2,*

1. Department of Microbial Biotechnology, Faculty of Basic Sciences and Advanced Technologies in Biology, University of Sci
2. Department of Laboratory Sciences, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences, Teh



The biofilm causes more than 60% of nosocomial infections and 65% human infections. bacteria in biofilms society are resistant against antibiotics. treatment of biofilm-related infections is difficult and problematic. in this review, we tried to investigate the fungi generating the cellobiose dehydrogenase enzyme for removing bacterial biofilms.


Many studies carried out to a more comprehensive understanding of the conditions that promote biofilm formation but more knowledge about the ecology and diversity of mixed microbial communities is still needed. common organisms that had cellobiose dehydrogenase activity to remove bacterial biofilms categorized in three groups including: white rot, mold, and soft rot fungi.


Combination of oxidoreductases activity with polysaccharide-hydrolyzing enzymes was resulted in bactericidal activity as well as removal of biofilms. in white rot group some fungi contained phanerochaete chrysosporium, schizophyllum commune, trametes versicolor, pycnoporus cinnabarinus, fomes annosus, phanerochaete sp. l1, polyporus dichrous, merulius tremellosus, phlebia radiate, pleurotus ostreatus, agaricus bisporusm, coriolus versicolor, flammulina velutipes, hericium erinaceus, and ganoderma gibbasum were studied. in mold group aspergillus niger, neurospora crassa, cladosporium species, stachybotrys spp., and monilia sitophila were considered. in soft rot group myceliophtore thermophile, humicola insolens, chaetomium spp., sclerotium rolfsii, and chaetomium cellulolyticum were studied.


The many problems caused by biofilms in the food and beverage industries and several outbreaks of foodborne illness attributed to biofilms make it obvious that prevention and removal of biofilms are important. the researchers seek to find ways to control and prevent the formation of biofilms. also, prevention of biofilm formation and microbial colonies society is the key to a successful strategy against infectious diseases. using the fungi generating the cellobiose dehydrogenase enzyme to remove bacterial biofilms is an alternative strategy for the most effective of treatment.


Cellobiose dehydrogenase production, fungi, bacterial biofilms.