Recent study about genetics of human obesity

Atefeh Sohan foroshan moghadam,1 Sajjad biglari,2,* Mohsen soosanabadi,3 Emran esmaeilzade,4

1. Nourdanesh Institute of Higher Education,Meyme,Esfahan,Iran
2. Genetics department, Jiroft university of medical sciences, Jiroft,Iran
3. Genetics research center, University of social welfare and rehabilitation sciences (USWR), Tehran, Iran.
4. Genetics research center, University of social welfare and rehabilitation sciences (USWR), Tehran, Iran.

Abstract

Introduction

Obesity has become a global epidemic and contributes to the increasing burden of type 2 diabetes, cardiovascular disease, stroke, some types of cancer, and premature death worldwide. obesity is highly heritable and arises from the interactions of multiple genes, environmental factors, and behavior. over 1 billion people are now overweight or obese, and the prevalence of these conditions is rising rapidly. remarkable new insights into the mechanisms that control body weight are providing an increasingly detailed framework for a better understanding of obesity pathogenesis.

Methods

In this paper, the authors reviewed recent developments in genetic epidemiologic research, focusing particularly on several promising genomic regions and obesity-related genes.

Results

Heritabilities for obesity-related phenotypes varied from 6% to 85% among various populations. key peripheral signals, such as leptin, insulin, and ghrelin, have been linked to hypothalamic neuropeptide systems, and the anatomic and functional networks that integrate these systems have begun to be elucidated

Conclusion

Integration of genetic epidemiology with functional genomics and proteomics studies will be required to fully understand the role of genetic variants in the etiology and prevention of obesity.

Keywords

Genetics , obesity,variants